- The most commonly used anti-emetics in anaesthesia practice are probably the 5HT3 antagonists, the -trons. Key examples would be ondansetron (4mg), tropisetron (2mg), granisetron (1mg). These drugs are usually given toward the end of general anaesthesia.
- Dexamethasone is a commonly used but occasionally controversial anti-emetic. It is probably as effective as the 5HT3 antagonists and is usually used at a dose of between 4 and 8 mg post induction of anaesthesia. The controversy surrounds the effects of steroid on infection, blood sugar and wound healing.
- Droperidol can be used in low doses (0.5mg), most often as a rescue therapy. There is a black box warning associated with the use of droperidol in the USA, regarding prolonged QT.
- Metoclopramide seems to be out of favour as an anti-emetic. it unlikely to be as effective as the three agents mentioned above. Its one useful property is that is pro-kinetic and may increase the rate of gastric emptying.